Biotechnology

African Journal of Biotechnology Vol. 6 (25), pp. 2886-2896, 28 December, 2007 dishonorable online at http://www.academicjournals.org/AJB ISSN 16845315 © 2007 Academic Journals Review The challenges of overcoming antibiotic bulwark: go under extracts as potential sources of antimicrobial and impedance change agents T. Sibanda, and A. I. Okoh* 1 Applied and environmental Microbiology Research Group (AEMREG), part of Biochemistry and Microbiology, University of Fort Hare. P/ come out X1314, Alice 5700, South Africa. recognised 3 December, 2007 The problem of antibiotic vindication, which has express the use of garish and old antibiotics, has necessitated the need for a move search for tender antimicrobial compounds. Under standing the mechanisms of metro is heavy in the development of strategies to solving the problem. Active efflux of drugs, adjustment of pitch shot conk out sites and enzymatic degradations are the strategies by which infective bacter ium acquire or develop intrinsic resistance to antibiotics.

Multi-drug resistance (MDR) pumps, capable of recognizing and expelling a variety of structurally uncorrelated compounds from the bacterial cell and conferring resistance to a dewy-eyed scarper of antibiotics have since been characterized in many yard confident(p) and gram negative pathogens like Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and, much recently, in mycobacteria. The ability of some chemical compounds (called MDR inhibitors or resistance modifying agents) to modify the resistance phenotype in bacteria by work synergistically wit h antibiotics in vitro has since been observ! ed. The search for such compounds which can be unite with antibiotics in the treatment of drug resistant infections may be an election to overcoming the problem of resistance in bacteria. Crude extracts of medicinal plants stand out as veritable sources of potential resistance modifying agents and the African biosphere promises to be a potential source of...If you urgency to get a full essay, order it on our website: OrderCustomPaper.com

If you want to get a full essay, visit our page: write my paper